A Rapid Esterification by Means of Mixed Anhydride and Its Application to Large-ring Lactonization

19792,163 citationsJournal Article

Authors

Junji Inanaga · Kyushu University

Kuniko Hirata · Kyushu University

Hiroko SAEKI · Kyushu University

Tsutomu Katsuki · Kyushu University

Masaru Yamaguchi · Kyushu University

Abstract

Abstract A rapid and mild esterification method using carboxylic 2,4,6-trichlorobenzoic anhydrides in the presence of 4-dimethylaminopyridine was developed. The method was also successfully applied to the synthesis of large-ring lactones, including Dl-2,4,6-tridemethyl-3-deoxymethynolide.

Topics & Keywords

Analytical Chemistry and Chromatography Synthetic Organic Chemistry Methods Analytical Methods in Pharmaceuticals

UN Sustainable Development Goals

Clean water and sanitation

Publication Details

Published in: Bulletin of the Chemical Society of Japan

Volume 52, Issue 7, pp. 1989-1993

DOI: 10.1246/bcsj.52.1989

Field-Weighted Citation Impact: 3.06