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ABSTRACT There is a paucity of research on depression and lesbian women. This is surprising given that large numbers of women experience depressive episodes and lesbian women in particular face an increased number of stressors related to their sexual orientation. This study explored how social support from family, social support from friends, relationship involvement, and sexual orientation disclosure related to and predicted depression for a sample of lesbian women. Information from 117 questionnaires was compiled from self-identified lesbians recruited through various lesbian-positive groups and snowball sampling. Results indicated significantly lower depression rates for women who were in a relationship and moderate negative correlations between depression and social support from family, social support from friends, and sexual orientation disclosure. Standard multiple regression analysis showed that 38% of the variability in depression scores was predicted by knowing the scores on the four independent variables. These results suggest that each of the independent variables has a significant effect on level of depression for lesbian women in the sample.