Enhanced NFκB and AP-1 transcriptional activity associated with antiestrogen resistant breast cancer

2007200 citationsJournal Articlegold Open Access

Authors

Yamei Zhou · Buck Institute for Research on Aging

Christina Yau · Buck Institute for Research on Aging

Joe W. Gray · University of California, San Francisco

Karen Chew · University of California, San Francisco

Shanaz H. Dairkee · California Pacific Medical Center

Dan H. Moore · California Pacific Medical Center

Urs Eppenberger

Abstract

Altogether, these findings implicate increased NFkappaB and AP-1 transcriptional responses with tamoxifen resistant breast cancer and early metastatic relapse, especially in younger patients. These findings also suggest that agents capable of preventing NFkappaB and AP-1 gene activation may prove useful in restoring the endocrine responsiveness of such high-risk ER-positive breast cancers.

Topics & Keywords

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: BMC Cancer

Volume 7, Issue 1, pp. 59-59

DOI: 10.1186/1471-2407-7-59

Field-Weighted Citation Impact: 7.79