Reactive Oxygen Species Play an Important Role in the Activation of Heat Shock Factor 1 in Ischemic-Reperfused Heart

1999114 citationsJournal Articlebronze Open Access

Authors

Junichiro Nishizawa · Japan Science and Technology Agency

Akira Nakai · Japan Science and Technology Agency

Katsuhiko Matsuda · Japan Science and Technology Agency

Masashi Komeda · Japan Science and Technology Agency

Toshihiko Ban · Japan Science and Technology Agency

Kazuhiro Nagata · Japan Science and Technology Agency

Abstract

Our findings demonstrate that ROSs play an important role in the activation of HSF1 and the accumulation of mRNA for HSP70 and HSP90 in the ischemic-reperfused heart.

Topics & Keywords

Heat shock proteins research Cardiac Ischemia and Reperfusion Thermoregulation and physiological responses

UN Sustainable Development Goals

Life below water

Publication Details

Published in: Circulation

Volume 99, Issue 7, pp. 934-941

DOI: 10.1161/01.cir.99.7.934

Field-Weighted Citation Impact: 2.24