Local Controlled Intramyocardial Delivery of Platelet-Derived Growth Factor Improves Postinfarction Ventricular Function Without Pulmonary Toxicity

2006146 citationsJournal Article

Authors

Abstract

Intramyocardial delivery of PDGF by self-assembling peptide NFs leads to long-term improvement in cardiac performance after experimental infarction without apparent pulmonary toxicity. Local myocardial protection may allow prevention of heart failure without systemic toxicity.

Topics & Keywords

Tissue Engineering and Regenerative Medicine Electrospun Nanofibers in Biomedical Applications Cardiac Structural Anomalies and Repair

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 114, Issue 7, pp. 637-644

DOI: 10.1161/circulationaha.106.639831

Field-Weighted Citation Impact: 12.01