Endothelium-Restricted Overexpression of Human Endothelin-1 Causes Vascular Remodeling and Endothelial Dysfunction

2004343 citationsJournal Article

Authors

Farhad Amiri · Hypertension Institute

Agostino Virdis · Hypertension Institute

Mário Fritsch Neves · Hypertension Institute

Marc Iglarz · Hypertension Institute

Nabil G. Seidah · Hypertension Institute

Rhian M. Touyz · Hypertension Institute

Timothy L. Reudelhuber ·

Abstract

In this new murine model of endothelium-restricted human preproET-1 overexpression, ET-1 caused structural remodeling and endothelial dysfunction of resistance vessels, consistent with a direct nonhemodynamic effect of ET-1 on the vasculature, at least in part through the activation of vascular NAD(P)H oxidase.

Topics & Keywords

Nitric Oxide and Endothelin Effects Cardiovascular Health and Disease Prevention Birth, Development, and Health

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 110, Issue 15, pp. 2233-2240

DOI: 10.1161/01.cir.0000144462.08345.b9

Field-Weighted Citation Impact: 8.14