Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis

20031,940 citationsJournal Article

Authors

Solbritt Rantapää‐Dahlqvist · Umeå University

B.A.W. de Jong · Radboud University Nijmegen

Ewa Berglin · Umeå University

Göran Hallmans · Umeå University

Göran Wadell · Umeå University

Hans Stenlund · Umeå University

Ulf Sundin · Stockholm University College of Music Education

Abstract

Anti-CCP antibody and RFs of all isotypes predated the onset of RA by several years. The presence of anti-CCP and IgA-RF predicted the development of RA, with anti-CCP antibody having the highest predictive value. This indicates that citrullination and the production of anti-CCP and RF autoantibodies are early processes in RA.

Topics & Keywords

Rheumatoid Arthritis Research and Therapies Systemic Lupus Erythematosus Research Monoclonal and Polyclonal Antibodies Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Arthritis & Rheumatism

Volume 48, Issue 10, pp. 2741-2749

DOI: 10.1002/art.11223

Field-Weighted Citation Impact: 46.34