VEGF and VEGFR polymorphisms affect clinical outcome in advanced renal cell carcinoma patients receiving first-line sunitinib

201278 citationsJournal Articlehybrid Open Access

Authors

Mario Scartozzi · Marche Polytechnic University

Maristella Bianconi · Marche Polytechnic University

Luca Faloppi · Marche Polytechnic University

Cristian Loretelli · Marche Polytechnic University

Alessandro Bittoni · Marche Polytechnic University

Michela Del Prete · Marche Polytechnic University

Riccardo Giampieri

Abstract

In our analysis, patients with TT polymorphism of rs833061, CC polymorphism of rs699947, CC polymorphism of rs2010963 and CG polymorphism of rs6877011 seem to have a worse PFS and OS when receiving first-line sunitinib.

Topics & Keywords

Renal cell carcinoma treatment Renal and related cancers Angiogenesis and VEGF in Cancer

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: British Journal of Cancer

Volume 108, Issue 5, pp. 1126-1132

DOI: 10.1038/bjc.2012.501

Field-Weighted Citation Impact: 9.77