High-mobility group box 1 activates caspase-1 and promotes hepatocellular carcinoma invasiveness and metastases

2012246 citationsJournal Articlebronze Open Access

Authors

Wei Yan · University of Pittsburgh Medical Center

Ying Chang · University of Pittsburgh Medical Center

Xiaoyan Liang · University of Pittsburgh Medical Center

Jon Cardinal · University of Pittsburgh Medical Center

Hai Huang · University of Pittsburgh Medical Center

Stephen H. Thorne · University of Pittsburgh Medical Center

Satdarshan P. Monga

Abstract

These results suggest that in hypoxic HCC cells, HMGB1 activates TLR4- and RAGE-signaling pathways to induce caspase-1 activation with the subsequent production of multiple inflammatory mediators, which, in turn, promote cancer invasion and metastasis.

Topics & Keywords

Advanced Glycation End Products research Eicosanoids and Hypertension Pharmacology Heme Oxygenase-1 and Carbon Monoxide

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Hepatology

Volume 55, Issue 6, pp. 1863-1875

DOI: 10.1002/hep.25572

Field-Weighted Citation Impact: 12.69