ProBDNF Collapses Neurite Outgrowth of Primary Neurons by Activating RhoA

2012145 citationsJournal Articlegold Open Access

Authors

Ying Sun · Flinders University

Yoon Lim · Flinders University

Fang Li · Flinders University

Shen Liu · Flinders University

Jianjun Lu · University of South Australia

Rainer Haberberger · Flinders University

Jinhua Zhong · University of South Australia

Abstract

proBDNF has an opposing role in neurite outgrowth to that of mature BDNF. Our observations suggest that proBDNF collapses neurites outgrowth and filopodial growth cones by activating RhoA through the p75NTR signaling pathway.

Topics & Keywords

Nerve injury and regeneration Neurogenesis and neuroplasticity mechanisms Signaling Pathways in Disease

Publication Details

Published in: PLoS ONE

Volume 7, Issue 4, pp. e35883-e35883

DOI: 10.1371/journal.pone.0035883

Field-Weighted Citation Impact: 5.23

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ProBDNF Collapses Neurite Outgrowth of Primary Neurons by Activating RhoA

Authors

Abstract

Topics & Keywords

Publication Details