EFFECT OF THE ANGIOGENESIS INHIBITOR CILENGITIDE (EMD 121974) ON GLIOBLASTOMA GROWTH IN NUDE MICE

2006128 citationsJournal Article

Authors

Shinya Yamada · Shonan Oiso Hospital

Xingyao Bu

Vazgen Khankaldyyan

Ignacio Gonzales-Gomez

J. Gordon McComb

Walter E. Laug

Abstract

This standardized brain tumor model is highly reproducible and useful for testing new treatment regimens. Cilengitide is highly effective in suppressing blood vessel growth, thereby controlling orthotopic growth of this glioblastoma cell line.

Topics & Keywords

Angiogenesis and VEGF in Cancer Cancer, Hypoxia, and Metabolism Glioma Diagnosis and Treatment

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Neurosurgery

Volume 59, Issue 6, pp. 1304-1312

DOI: 10.1227/01.neu.0000245622.70344.be

Field-Weighted Citation Impact: 3.12