Fatty Acids and Hypoxia Stimulate the Expression and Secretion of the Adipokine ANGPTL4 (Angiopoietin-Like Protein 4/ Fasting-Induced Adipose Factor) by Human Adipocytes

201166 citationsJournal Articlegold Open Access

Authors

Pedro González‐Muniesa · University of Liverpool

Cristiane de Oliveira · University of Liverpool

Fátima Pérez de Heredia · University of Liverpool

Mary P. Thompson · University of Liverpool

Abstract

The expression and secretion of ANGPTL4 by human adipocytes is upregulated by both hypoxia and fatty acids. The stimulatory effect of fatty acids on ANGPTL4 production is augmented under hypoxic conditions.

Topics & Keywords

Lipid metabolism and disorders Diabetes, Cardiovascular Risks, and Lipoproteins Cancer, Hypoxia, and Metabolism

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Lifestyle Genomics

Volume 4, Issue 3, pp. 146-153

DOI: 10.1159/000327774

Field-Weighted Citation Impact: 4.29