Methods to Study GPI Anchoring of Proteins

201023 citationsReview

Authors

Tamara L. Hendrickson · Wayne State University

Abstract

Dropping anchor: Glycosylphosphatidylinositol (GPI) membrane-anchored proteins noncovalently associate with the plasma membrane and can have an impact on oncogenesis and some infectious diseases. The GPI anchor biosynthetic machinery and GPI-T, the transamidase that attaches them to proteins, are complicated, membrane-associated enzymes that are only beginning to be understood.

Topics & Keywords

Trypanosoma species research and implications Lysosomal Storage Disorders Research Glycosylation and Glycoproteins Research

Publication Details

Published in: ChemBioChem

Volume 11, Issue 5, pp. 623-636

DOI: 10.1002/cbic.200900704

Field-Weighted Citation Impact: 2.04

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Methods to Study GPI Anchoring of Proteins

Authors

Abstract

Topics & Keywords

Publication Details