Intrathecal Coadministration of Bupivacaine Diminshes Morphine Dose Progression During Long-term Intrathecal Infusion in Cancer Patients

1999130 citationsJournal Article

Authors

R.T.M. van Dongen · Radboud University Nijmegen

J. van Egmond · Radboud University Nijmegen

Abstract

The diminished intrathecal morphine dose increase in the combination group is considered to be due to a synergistic effect of bupivacaine on the intrathecal morphine-induced antinociception. A dose increment during long-term intrathecal infusion in cancer patients appears to be related to both disease progression and tolerance phenomena.

Topics & Keywords

Pain Management and Opioid Use Anesthesia and Pain Management Pain Mechanisms and Treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Journal of Pain

Volume 15, Issue 3, pp. 166-172

DOI: 10.1097/00002508-199909000-00002

Field-Weighted Citation Impact: 3.95