Histogenesis‐specific expression of fibroblast activation protein and dipeptidylpeptidase‐IV in human bone and soft tissue tumours

200994 citationsJournal Articlebronze Open Access

Authors

Osamu Dohi · Tohoku University

Haruo Ohtani · National Hospital Organization Mito Medical Center

Masahito Hatori

Elichi Sato · Tohoku University

Masami Hosaka

Hiroshi Nagura · Tohoku University

Eiji Itoi

S. Kokubun

Abstract

Our data suggest that FAP and DPP-IV are consistently expressed in bone and soft tissue tumour cells that are histogenetically related to activated fibroblasts and/or myofibroblasts, irrespective of their malignancy. DPP-IV is also expressed in monocyte-macrophage lineage cells.

Topics & Keywords

Peptidase Inhibition and Analysis Protease and Inhibitor Mechanisms Ubiquitin and proteasome pathways

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Histopathology

Volume 55, Issue 4, pp. 432-440

DOI: 10.1111/j.1365-2559.2009.03399.x

Field-Weighted Citation Impact: 1.03