Estrogen Carcinogenesis in Breast Cancer

20061,856 citationsReview

Authors

James D. Yager · Johns Hopkins University

Nancy E. Davidson · Sidney Kimmel Comprehensive Cancer Center

Abstract

Estrogen exposure is a major determinant of the risk of breast cancer. This article reviews how genotoxic, mutagenic metabolites of estrogen and stimulation of tissue growth by the hormone participate in the pathogenesis of breast cancer.

Topics & Keywords

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 354, Issue 3, pp. 270-282

DOI: 10.1056/nejmra050776

Field-Weighted Citation Impact: 66.67