Subanesthetic Effects of the Noncompetitive NMDA Antagonist, Ketamine, in Humans

19943,317 citationsJournal Article

Authors

John H. Krystal · Veterans Health Administration

Abstract

These data indicate that N-methyl-D-aspartate antagonists produce a broad range of symptoms, behaviors, and cognitive deficits that resemble aspects of endogenous psychoses, particularly schizophrenia and dissociative states.

Topics & Keywords

Treatment of Major Depression Tryptophan and brain disorders Schizophrenia research and treatment

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Archives of General Psychiatry

Volume 51, Issue 3, pp. 199-199

DOI: 10.1001/archpsyc.1994.03950030035004

Field-Weighted Citation Impact: 34.00