Aganirsen Antisense Oligonucleotide Eye Drops Inhibit Keratitis-Induced Corneal Neovascularization and Reduce Need for Transplantation

2014110 citationsJournal Articlehybrid Open Access

Authors

Claus Cursiefen · University Hospital Cologne

Eric Viaud

Felix Bock · University Hospital Cologne

Bernard Geudelin

Antoine Ferry · Laboratoire Vision Action Cognition

Abstract

This first phase III study on a topical inhibitor of corneal angiogenesis showed that aganirsen eye drops significantly inhibited corneal neovascularization in patients with keratitis. The need for transplantation was significantly reduced in patients with viral keratitis and central neovascularization. Topical application of aganirsen was safe and well tolerated.

Topics & Keywords

Corneal Surgery and Treatments Corneal surgery and disorders Ocular Surface and Contact Lens

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Ophthalmology

Volume 121, Issue 9, pp. 1683-1692

DOI: 10.1016/j.ophtha.2014.03.038

Field-Weighted Citation Impact: 7.51