A facilely synthesized amino-functionalized metal–organic framework for highly specific and efficient enrichment of glycopeptides

2014115 citationsJournal Article

Authors

Yiwei Zhang · Peking University

Ze Li · Beijing National Laboratory for Molecular Sciences

Qiang Zhao · Institute of Bioorganic Chemistry

Ying‐Lin Zhou · Peking University

Huwei Liu · Institute of Bioorganic Chemistry

Xin‐Xiang Zhang · Beijing National Laboratory for Molecular Sciences

Abstract

A facilely synthesized amino-functionalized metal-organic framework (MOF) MIL-101(Cr)-NH2 was first applied for highly specific glycopeptide enrichment based on the hydrophilic interactions. With the special characteristics of the MOF, the material performed well in selectivity and sensitivity for both standard glycoprotein samples and complex biological samples.

Topics & Keywords

Glycosylation and Glycoproteins Research Carbohydrate Chemistry and Synthesis Advanced biosensing and bioanalysis techniques

Publication Details

Published in: Chemical Communications

Volume 50, Issue 78, pp. 11504-11506

DOI: 10.1039/c4cc05179c

Field-Weighted Citation Impact: 6.14

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A facilely synthesized amino-functionalized metal–organic framework for highly specific and efficient enrichment of glycopeptides

Authors

Abstract

Topics & Keywords

Publication Details