Hepatitis C Virus Co-Infection Increases the Risk of Anti-Tuberculosis Drug-Induced Hepatotoxicity among Patients with Pulmonary Tuberculosis

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Authors

Nino Lomtadze · National Center for Tuberculosis and Lung Disease

Lali Kupreishvili · National Center for Tuberculosis and Lung Disease

Archil Salakaia · National Center for Tuberculosis and Lung Disease

Sergo Vashakidze · National Center for Tuberculosis and Lung Disease

Lali Sharvadze · AIDS and Clinical Immunology Research Center

Russell R. Kempker · Emory University

Abstract

A high prevalence of HCV co-infection was found among patients with TB in Georgia. Drug-induced hepatotoxicity was significantly associated with HCV co-infection but severe drug-induced hepatotoxicity (WHO grade III or IV) was rare.

Topics & Keywords

Hepatitis C virus research Drug-Induced Hepatotoxicity and Protection Tuberculosis Research and Epidemiology

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS ONE

Volume 8, Issue 12, pp. e83892-e83892

DOI: 10.1371/journal.pone.0083892

Field-Weighted Citation Impact: 1.85