Vitamin B₁₂ Deficiency After Gastric Bypass Surgery for Obesity

Brief Reports1 October 1984Vitamin B12 Deficiency After Gastric Bypass Surgery for ObesityROBERT F. SCHILLING, M.D., PAUL N. GOHDES, M.D., GORDON H. HARDIE, M.D.ROBERT F. SCHILLING, M.D.Search for more papers by this author, PAUL N. GOHDES, M.D.Search for more papers by this author, GORDON H. HARDIE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-4-501 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptGastric bypass surgery for obesity is a popular and partially effective operation. There are few studies of changes in chemistry after this operation. Wernicke-Korsakoff encephalopathy was seen in two patients at 3 months after bypass surgery (1). In one patient megaloblastic anemia appeared 6 years after surgery (2). Serum vitamin B12was below normal in 26% of 69 patients (3). We are not aware of studies of vitamin B12absorption or of the effect of oral supplementation in patients who have had bypass surgery. After a low serum vitamin B12level was found in several patients, this study was done....References1. HAID R, GUTMANN L, and CROSBY T. Wernicke-Korsakoff encephalopathy after gastric plication. JAMA. 1982;247:2566-7. CrossrefMedlineGoogle Scholar2. CROWLEY L. Megaloblastic anemia following gastric bypass. J Am Diet Assoc. 1982;81:608. Google Scholar3. HALVERSON J, ZUCKERMAN G, KOEHLER R, GENTRY K, MICHAEL H, and DESCHRYVER-KECSKEMETI K. Gastric bypass for morbid obesity: a medical-surgical assessment. Ann Surg. 1981;194:152-60. CrossrefMedlineGoogle Scholar4. ALDEN J. Gastric bypass and jejunoileo bypass: a comparison in the treatment of morbid obesity. Arch Surg. 1977;112:799-805. CrossrefMedlineGoogle Scholar5. SCHILLING R, CLATANOFF D, and KORST D. Intrinsic factor studies: III. Further observations utilizing the urinary radioactivity test in subjects with achlorhydria, pernicious anemia, or a total gastrectomy. J Lab Clin Med. 1956;45:926-34. Google Scholar6. GRÄSBECK R. Studies on the vitamin B-12 binding principle and other biocolloids of human gastric juice. Acta Med Scand. 1956;(suppl 314):1-87. Google Scholar7. ABELS J and SCHILLING R. Protection of intrinsic factor by vitamin B-12. J Lab Clin Med. 1964;64:375-84. MedlineGoogle Scholar8. DOSCHERHOLMEN A and SWAIM W. Impaired assimilation of egg Co57 vitamin B12 in patients with hypochlorhydria and achlorhydria and after gastric resection. Gastroenterology. 1973;64:913-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROBERT F. SCHILLING, M.D.; PAUL N. GOHDES, M.D.; GORDON H. HARDIE, M.D.Affiliations: University of Wisconsin; Madison, Wisconsin; and Theda Clark Hospital Neenah, Wisconsin PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPerioperative Management of Patients With Neuromuscular DisordersMicro-nutritional, Endocrine, and Metabolic Complications in Bariatric Surgery-Case CapsulesRole of Functional Biomarkers to Identify Early Vitamin B12 Deficiency in Patients with Sleeve Gastrectomy: A Cross-Sectional StudyAnemia Following Bariatric SurgeryNeuropathy by folic acid supplementation in a patient with anaemia and an untreated cobalamin deficiency: a case reportDo specialized bariatric multivitamins lower deficiencies after RYGB?Different Supplementation Regimes to Treat Perioperative Vitamin B12 Deficiencies in Bariatric Surgery: a Systematic ReviewImproving Bariatric Patient Aftercare Outcome by Improved Detection of a Functional Vitamin B12 DeficiencyComplications of Bariatric SurgeryInterdisciplinary European Guidelines on Metabolic and Bariatric SurgeryDiagnosis and management of clinical and subclinical cobalamin deficiencies: Why controversies persist in the age of sensitive metabolic testingNutritional and Metabolic Management of Obesity and the Metabolic Syndrome in the Patient with Chronic Kidney DiseasePrevalence of Anemia and Related Deficiencies in the First Year following Laparoscopic Gastric Bypass for Morbid ObesityMandatory fortification of the food supply with cobalamin: an idea whose time has not yet comePerioperative Management of Patients with Neuromuscular DisordersNeurologic Presentations of Nutritional DeficienciesBARIATRIC SURGICAL PROCEDURES IN ADOLESCENCENutritional Deficiencies in Obesity and After Bariatric SurgerySurgical Management of Obesity and Postoperative CareAnemia Following Roux-en-Y Surgery for Morbid Obesity: A ReviewHow I treat cobalamin (vitamin B12) deficiencyASMBS Allied Health Nutritional Guidelines for the Surgical Weight Loss PatientSurgical Management Strategies for Extremely Obese AdolescentsEfficacy and Safety of Fortification and Supplementation with Vitamin B 12 : Biochemical and Physiological EffectsEstrategia terapéutica del exceso de peso en el adolescente y en su familiaNeuromuscular Complications of Bariatric SurgeryCarences nutritionnelles après bypass gastrique : diagnostic, prévention et traitementsInter-disciplinary European guidelines on surgery of severe obesityInterdisciplinary European Guidelines for Surgery for Severe (Morbid) ObesityNutritional deficiency after gastric bypass: diagnosis, prevention and treatmentNutritional NeuropathiesNutrition and Gastrointestinal Complications of Bariatric SurgeryGastrointestinal Complications of Bariatric SurgeryNutritional consequences of bariatric surgeryNeurologic complications after surgery for obesityNutrition and Roux-en-Y Gastric Bypass SurgeryRole of the Primary Care Physician Before and After Weight-Loss SurgeryAlterations in Gastrointestinal Physiology after Roux-En-Y Gastric BypassCriteria for Patient Selection and Multidisciplinary Evaluation and Treatment of the Weight Loss Surgery PatientBeriberi after gastric bypass surgery in adolescenceBone metabolism and risk of secondary hyperparathyroidism 12 months after gastric banding in obese pre-menopausal womenManaging the Obese Patient After Bariatric Surgery: A Case Report of Severe Malnutrition and Review of the LiteratureSurgery in the Management of Severe ObesityVitamin B-12 deficiency after gastric surgery for obesity10 Malabsorption of food cobalaminThe role of gastric surgery in the multidisciplinary management of severe obesityLate results of gastric bypass surgery for morbid obesity.Prospective evaluation of gastric acid secretion and cobalamin absorption following gastric bypass for clinically severe obesityNutritional Vitamin B 12 Deficiency in a Breastfed Infant Following Maternal Gastric BypassCobalamin absorption and hematologic status after two types of gastric surgery for obesityEvidence for diminished B12 absorption after gastric bypass: oral supplementation does not prevent low plasma B12 levels in bypass patients.Metabolic risk of obesity surgery and long-term follow-upIron Deficiency and Megaloblastic AnemiasRecent Developments in the Prompt-Gamma Total Body Nitrogen Measurement Facility of the Toronto General HospitalAbsence of luminal intrinsic factor after gastric bypass surgery for morbid obesityVitamin E, vitamin B-6, vitamin B-12, and folate status of gastric bypass surgery patientsVitamin and Mineral Deficiencies Following Obesity SurgeryNEURAL TUBE DEFECTS AFTER GASTRIC BYPASSVitamin B12 Deficiency After Gastric SurgeryROBERT LEBOW, M.D., MAY L. VOTAW, M.D., STEPHEN ROYAL, M.D.Managing Micronutrient Deficiencies in the Bariatric Surgical Patient 1 October 1984Volume 101, Issue 4Page: 501-502KeywordsBrain diseasesMegaloblastic anemiaObesitySurgeryVitamin B12 deficiency ePublished: 1 December 2008 Issue Published: 1 October 1984 PDF downloadLoading ...