Hypermethylated promoter region of <i>DR3</i>, the death receptor 3 gene, in rheumatoid arthritis synovial cells

2006143 citationsJournal Article

Authors

Nozomi Takami

Kayo Osawa · Kobe University

Yasushi Miura · Kobe University Hospital

Koichiro Komai · Kobe University

Mariko Taniguchi · Kobe University

Masahiko Shiraishi · National Cancer Research Institute

Keizo Sato · Kobe Rosai Hospital

Abstract

The CpG island in the DR3 gene promoter was specifically methylated to down-modulate the expression of DR-3 protein in rheumatoid synovial cells, which may provide resistance to apoptosis in RA synovial cells.

Topics & Keywords

Cell death mechanisms and regulation Hepatitis B Virus Studies interferon and immune responses

UN Sustainable Development Goals

Life below water

Publication Details

Published in: Arthritis & Rheumatism

Volume 54, Issue 3, pp. 779-787

DOI: 10.1002/art.21637

Field-Weighted Citation Impact: 1.32