Tissue Plasminogen Activator and Risk of Myocardial Infarction

1997132 citationsJournal Article

Authors

Johanna G. van der Bom · Cal Humanities

Peter de Knijff · Cal Humanities

F. Haverkate · Cal Humanities

Michiel L. Bots · Cal Humanities

Piet Meijer · Cal Humanities

Paulus T.V.M. de Jong · Cal Humanities

Albert Hofman · Cal Humanities

Abstract

This study provides evidence for an independent association of the insertion allele of the insertion/deletion polymorphism in the TPA gene with nonfatal MI. Increased TPA antigen is associated with an increased risk of MI; however, this association was not independent of cardiovascular disease risk factors.

Topics & Keywords

Protease and Inhibitor Mechanisms Biomarkers in Disease Mechanisms Adipokines, Inflammation, and Metabolic Diseases

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 95, Issue 12, pp. 2623-2627

DOI: 10.1161/01.cir.95.12.2623

Field-Weighted Citation Impact: 3.86