Quantifying Residual HIV-1 Replication in Patients Receiving Combination Antiretroviral Therapy

1999824 citationsJournal Articlebronze Open Access

Authors

Linqi Zhang · Rockefeller University

Bharat Ramratnam · Rockefeller University

Klara Tenner‐Racz · Bernhard Nocht Institute for Tropical Medicine

Yuxian He · Rockefeller University

Mika Vesanen · Rockefeller University

Sharon R. Lewin · Rockefeller University

Andrew H. Talal ·

Abstract

These findings suggest that combination antiretroviral regimens suppress HIV-1 replication in some but not all patients. Given the half-life of latently infected CD4 lymphocytes of about six months, it may require many years of effective antiretroviral treatment to eliminate this reservoir of HIV-1.

Topics & Keywords

HIV Research and Treatment HIV/AIDS drug development and treatment HIV/AIDS Research and Interventions

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 340, Issue 21, pp. 1605-1613

DOI: 10.1056/nejm199905273402101

Field-Weighted Citation Impact: 29.06