c-Myc Is Required for Maintenance of Glioma Cancer Stem Cells

2008421 citationsJournal Articlegold Open Access

Authors

Jialiang Wang · Duke University

Hui Wang · Duke University

Zhizhong Li · Duke University Hospital

Qiulian Wu · Duke University Hospital

Justin D. Lathia · Duke Medical Center

Roger E. McLendon · Duke University Hospital

Anita B. Hjelmeland ·

Abstract

These findings support a central role of c-Myc in regulating proliferation and survival of glioma cancer stem cells. Targeting core stem cell pathways may offer improved therapeutic approaches for advanced cancers.

Topics & Keywords

Cancer Cells and Metastasis MicroRNA in disease regulation Glioma Diagnosis and Treatment

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS ONE

Volume 3, Issue 11, pp. e3769-e3769

DOI: 10.1371/journal.pone.0003769

Field-Weighted Citation Impact: 9.18