Alterations of Sarcoplasmic Reticulum Proteins in Failing Human Dilated Cardiomyopathy

1995536 citationsJournal Article

Authors

Markus Meyer · Shionogi (Japan)

Wolfgang Schillinger · Shionogi (Japan)

Burkert Pieske · Shionogi (Japan)

Christian Holubarsch · Shionogi (Japan)

Claus Heilmann · Shionogi (Japan)

Herbert Posival · Shionogi (Japan)

Goro Kuwajima ·

Abstract

Levels of SR proteins involved in calcium binding and release are unchanged in failing dilated cardiomyopathy. In contrast, protein levels of calcium ATPase involved in SR calcium uptake are reduced in the failing myocardium. Moreover, SR calcium ATPase is decreased relative to its inhibitory protein, phospholamban.(ABSTRACT TRUNCATED AT 250 WORDS)

Topics & Keywords

Cardiovascular Effects of Exercise Viral Infections and Immunology Research Cardiomyopathy and Myosin Studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 92, Issue 4, pp. 778-784

DOI: 10.1161/01.cir.92.4.778

Field-Weighted Citation Impact: 17.87