CNS 7056

2007389 citationsJournal Articlebronze Open Access

Authors

Gavin J. Kilpatrick

Margaret McIntyre · Office of the Chief Scientist

Richard F. Cox

Jeffrey A. Stafford · Takeda (United States)

Gregory J. Pacofsky · Scynexis (United States)

Gwyer G. Lovell · Office of the Chief Scientist

Robert P. Wiard · Office of the Chief Scientist

Paul L. Feldman

Abstract

CNS 7065 is a high-affinity and selective ligand for the benzodiazepine site on the GABAA receptor. CNS 7056 does not show selectivity between GABAA receptor subtypes. CNS 7056 is a potent sedative in rodents with a short duration of action. Inhibition of substantia nigra pars reticulata firing and the inhibition of the effects of CNS 7056 by flumazenil show that it acts at the brain benzodiazepine receptor.

Topics & Keywords

Neuroscience and Neuropharmacology Research Memory and Neural Mechanisms Neurotransmitter Receptor Influence on Behavior

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Anesthesiology

Volume 107, Issue 1, pp. 60-66

DOI: 10.1097/01.anes.0000267503.85085.c0

Field-Weighted Citation Impact: 1.51