Isolated Limb Perfusion with Tumor Necrosis Factor and Melphalan for Limb Salvage in 186 Patients with Locally Advanced Soft Tissue Extremity Sarcomas

1996456 citationsJournal Articlegreen Open Access

Authors

Alexander M.M. Eggermont · Sheba Medical Center

Heimen Schraffordt Koops

Albertus N. van Geel · Rotterdam University of Applied Sciences

Abstract

In the setting of isolated limb perfusion, TNF is an active anticancer drug in patients. The ILP with TNF + melphalan can be performed safely in many centers and is an effective induction treatment with a high response rate that can achieve limb salvage in patients with locally advanced extremity soft tissue sarcoma.

Topics & Keywords

Sarcoma Diagnosis and Treatment Surgical site infection prevention Reconstructive Surgery and Microvascular Techniques

Publication Details

Published in: Annals of Surgery

Volume 224, Issue 6, pp. 756-765

DOI: 10.1097/00000658-199612000-00011

Field-Weighted Citation Impact: 27.07

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Isolated Limb Perfusion with Tumor Necrosis Factor and Melphalan for Limb Salvage in 186 Patients with Locally Advanced Soft Tissue Extremity Sarcomas

Authors

Abstract

Topics & Keywords

Publication Details