Additive Effect of Polymorphisms in the <i>IL-6</i>, <i>LTA</i>, and <i>TNF</i>-α Genes and Plasma Fatty Acid Level Modulate Risk for the Metabolic Syndrome and Its Components

LTA, TNF-alpha, and IL-6 genotype interactions increased MetS risk, which was further exacerbated by a low plasma polyunsaturated to saturated fat exposure, indicating important modulation of genetic risk by dietary fat exposure.