Safety of Cell Therapy with Mesenchymal Stromal Cells (SafeCell): A Systematic Review and Meta-Analysis of Clinical Trials

20121,131 citationsReviewgold Open Access

Authors

Manoj M. Lalu · Ottawa Hospital Research Institute

Lauralyn McIntyre · Ottawa Hospital Research Institute

Christina Pugliese · Ottawa Hospital Research Institute

Dean Fergusson · Ottawa Hospital Research Institute

Brent W. Winston · University of Calgary

John C. Marshall · University of Toronto

John Granton

Abstract

Based on the current clinical trials, MSC therapy appears safe. However, further larger scale controlled clinical trials with rigorous reporting of adverse events are required to further define the safety profile of MSCs.

Topics & Keywords

Mesenchymal stem cell research Renal and related cancers Tissue Engineering and Regenerative Medicine

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS ONE

Volume 7, Issue 10, pp. e47559-e47559

DOI: 10.1371/journal.pone.0047559

Field-Weighted Citation Impact: 33.07