Relative role of<i>APC</i>and<i>MUTYH</i>mutations in the pathogenesis of familial adenomatous polyposis

At least two genes are associated with the FAP phenotype. APC mutations account for the majority of cases, while MUTYH mutations can be observed in 10% of patients. There are few but definite differences between APC- and MUTYH-associated FAP, such as age at diagnosis and pattern of transmission.