Translocation of Inhaled Ultrafine Manganese Oxide Particles to the CentralNervous System

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Authors

Alison Elder · University of Rochester

Robert Gelein · University of Rochester

Vanessa Silva · University of Rochester

Tessa Feikert · University of Rochester

Lisa A. Opanashuk · University of Rochester

Janet Carter · Procter & Gamble (United States)

Russell M. Potter ·

Abstract

We conclude that the olfactory neuronal pathway is efficient for translocating inhaled Mn oxide as solid UFPs to the central nervous system and that this can result in inflammatory changes. We suggest that despite differences between human and rodent olfactory systems, this pathway is relevant in humans.

Topics & Keywords

Heavy Metal Exposure and Toxicity Mercury impact and mitigation studies Electrochemical Analysis and Applications

Publication Details

Published in: Environmental Health Perspectives

Volume 114, Issue 8, pp. 1172-1178

DOI: 10.1289/ehp.9030

Field-Weighted Citation Impact: 37.51

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Translocation of Inhaled Ultrafine Manganese Oxide Particles to the CentralNervous System

Authors

Abstract

Topics & Keywords

Publication Details