AVX-470

201363 citationsJournal Articlebronze Open Access

Authors

Kailash C. Bhol · Avaxia Biologics (United States)

Daniel E. Tracey · Avaxia Biologics (United States)

Brenda Lemos · Avaxia Biologics (United States)

Gregory D. Lyng

Emma Erlich · Avaxia Biologics (United States)

David M. Keane · Avaxia Biologics (United States)

Michael S. Quesenberry · Avaxia Biologics (United States)

Abstract

AVX-470 is a novel polyclonal anti-TNF antibody with an in vitro activity profile comparable to that of infliximab. Oral administration of a surrogate antibody specific for mouse TNF is effective in treating mouse models of IBD, delivering the anti-TNF to the site of inflammation with minimal systemic exposure.

Topics & Keywords

Inflammatory Bowel Disease Microscopic Colitis Helicobacter pylori-related gastroenterology studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Inflammatory Bowel Diseases

Volume 19, Issue 11, pp. 2273-2281

DOI: 10.1097/mib.0b013e3182a11958

Field-Weighted Citation Impact: 4.88