Negative Correlation between Brain Glutathione Level and Negative Symptoms in Schizophrenia: A 3T 1H-MRS Study

2008205 citationsJournal Articlegold Open Access

Authors

Daisuke Matsuzawa · Chiba University

Takayuki Obata

Yukihiko Shirayama · Chiba University

Hiroi Nonaka

Yôko Kanazawa

Eiji Yoshitome

Jun‐ichi Takanashi · Kameda Medical Center

Tsuyoshi Matsuda · Yokogawa Electric (Japan)

Eiji Shimizu

Abstract

These results suggest that GSH levels in the posterior medial frontal cortex may be related to negative symptoms in schizophrenic patients. Therefore, agents that increase GSH levels in the brain could be potential therapeutic drugs for negative symptoms in schizophrenia.

Topics & Keywords

Amino Acid Enzymes and Metabolism Tryptophan and brain disorders Sulfur Compounds in Biology

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS ONE

Volume 3, Issue 4, pp. e1944-e1944

DOI: 10.1371/journal.pone.0001944

Field-Weighted Citation Impact: 7.36