Synergistic Inhibition of Lung Tumorigenesis by a Combination of Green Tea Polyphenols and Atorvastatin

200868 citationsJournal Articlebronze Open Access

Authors

Gang Lü · Rutgers, The State University of New Jersey

Hang Xiao · Rutgers, The State University of New Jersey

Hui You · Rutgers, The State University of New Jersey

Yong Lin · Rutgers Cancer Institute of New Jersey

Huanyu Jin · Rutgers, The State University of New Jersey

Blake Snagaski · Rutgers, The State University of New Jersey

Chung S. Yang

Abstract

The present work showed that PPE and atorvastatin synergistically inhibited 4-(methylnitrosaminao)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in mice and the growth of lung cancer H1299 and H460 cells, possibly through enhanced apoptosis. The results provide leads for future research on the application of this combination for the prevention and treatment of lung cancer.

Topics & Keywords

Cancer, Lipids, and Metabolism Cancer-related Molecular Pathways Ferroptosis and cancer prognosis

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Cancer Research

Volume 14, Issue 15, pp. 4981-4988

DOI: 10.1158/1078-0432.ccr-07-1860

Field-Weighted Citation Impact: 2.74