The Effects of Airway Microbiome on Corticosteroid Responsiveness in Asthma

2013358 citationsJournal Articlegreen Open Access

Authors

Elena Goleva · Pediatrics and Genetics

Leisa Jackson · National Jewish Health

J. Kirk Harris · University of Colorado Denver

Charles E. Robertson · University of Colorado Boulder

E. Rand Sutherland · National Jewish Health

Clifton F. Hall · National Jewish Health

James T. Good

Abstract

A subset of subjects with CR asthma demonstrates airway expansion of specific gram-negative bacteria, which trigger TAK1/MAPK activation and induce corticosteroid resistance. TAK1 inhibition restored cellular sensitivity to corticosteroids.

Topics & Keywords

Asthma and respiratory diseases Gut microbiota and health Dermatology and Skin Diseases

Publication Details

Published in: American Journal of Respiratory and Critical Care Medicine

Volume 188, Issue 10, pp. 1193-1201

DOI: 10.1164/rccm.201304-0775oc

Field-Weighted Citation Impact: 12.86

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The Effects of Airway Microbiome on Corticosteroid Responsiveness in Asthma

Authors

Abstract

Topics & Keywords

Publication Details