Increased Infiltration of Tumor Associated Macrophages is Associated With Poor Prognosis of Bladder Carcinoma In Situ After Intravesical Bacillus Calmette-Guerin Instillation

No AccessJournal of UrologyInvestigative Urology1 Apr 2009Increased Infiltration of Tumor Associated Macrophages is Associated With Poor Prognosis of Bladder Carcinoma In Situ After Intravesical Bacillus Calmette-Guerin Instillationis accompanied byTumor Associated Macrophages: Predicting Bacillus Calmette-Guerin Immunotherapy Outcomesis companion ofOncological Followup After Radical Cystectomy for Bladder Cancer—Is There Any Benefit?Molecular Analyte Profiling of the Early Events and Tissue Conditioning Following Intravesical Bacillus Calmette-Guerin Therapy in Patients With Superficial Bladder CancerLong-Term Outcome of Simultaneous Transurethral Resection of Bladder Tumor and Prostate in Patients With Nonmuscle Invasive Bladder Tumor and Bladder Outlet Obstruction Hitoshi Takayama, Kazuo Nishimura, Akira Tsujimura, Yasutomo Nakai, Masashi Nakayama, Katsuyuki Aozasa, Akihiko Okuyama, and Norio Nonomura Hitoshi TakayamaHitoshi Takayama , Kazuo NishimuraKazuo Nishimura , Akira TsujimuraAkira Tsujimura , Yasutomo NakaiYasutomo Nakai , Masashi NakayamaMasashi Nakayama , Katsuyuki AozasaKatsuyuki Aozasa , Akihiko OkuyamaAkihiko Okuyama , and Norio NonomuraNorio Nonomura View All Author Informationhttps://doi.org/10.1016/j.juro.2008.11.090AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Tumor associated macrophages can regulate the growth of various cancers positively or negatively. Intravesical bacillus Calmette-Guerin instillation is now gold standard treatment for bladder carcinoma in situ. We investigated the correlation between tumor associated macrophages infiltrating bladder carcinoma in situ and the response to intravesical bacillus Calmette-Guerin therapy. Materials and Methods: We examined paraffin embedded tissues from 41 patients with bladder carcinoma in situ who received intravesical bacillus Calmette-Guerin therapy. Tumor associated macrophages were immunohistochemically stained by anti-CD68 monoclonal antibody. Results: The median number of tumor associated macrophages infiltrating among cancer cells and the number in the lamina propria were 4 and 24, respectively. Recurrent carcinoma in situ was found in 4.8% of cases with a lower cancer cell tumor associated macrophage count but in 47.6% of those with a higher cancer cell tumor associated macrophage count (less than 4 vs 4 or greater). Recurrence was found in 31.8% of patients with a lower lamina propria tumor associated macrophage count but in 21.1% of those with a higher lamina propria tumor associated macrophage count (less than 25 vs 25 or greater). The median ratio of tumor associated macrophages among cancer cells vs in the lamina propria was 0.2. Recurrence-free survival was significantly better in patients with a lower cancer cell tumor associated macrophage count (p = 0.0002). Those with a lower cancer cell-to-lamina propria tumor associated macrophage ratio had a higher recurrence-free rate (p <0.0001). Multivariate analysis revealed that the cancer cell tumor associated macrophage count and the cancer cell-to-lamina propria tumor associated macrophage ratio can be prognostic factors for bladder carcinoma in situ. 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Google Scholar Departments of Urology and Pathology (KA), Osaka University Graduate School of Medicine, Suita, Japan© 2009 by American Urological AssociationFiguresReferencesRelatedDetailsRelated articlesJournal of Urology23 Feb 2009Tumor Associated Macrophages: Predicting Bacillus Calmette-Guerin Immunotherapy OutcomesJournal of Urology23 Feb 2009Oncological Followup After Radical Cystectomy for Bladder Cancer—Is There Any Benefit?Journal of Urology23 Feb 2009Molecular Analyte Profiling of the Early Events and Tissue Conditioning Following Intravesical Bacillus Calmette-Guerin Therapy in Patients With Superficial Bladder CancerJournal of Urology23 Feb 2009Long-Term Outcome of Simultaneous Transurethral Resection of Bladder Tumor and Prostate in Patients With Nonmuscle Invasive Bladder Tumor and Bladder Outlet Obstruction Volume 181Issue 4April 2009Page: 1894-1900 Advertisement Copyright & Permissions© 2009 by American Urological AssociationKeywordsurinary bladdermacrophagesprognosisBCG vaccinecarcinoma in situMetricsAuthor Information Hitoshi Takayama More articles by this author Kazuo Nishimura More articles by this author Akira Tsujimura More articles by this author Yasutomo Nakai More articles by this author Masashi Nakayama More articles by this author Katsuyuki Aozasa More articles by this author Akihiko Okuyama More articles by this author Norio Nonomura More articles by this author Expand All Advertisement PDF downloadLoading ...