Formation of Toxic Oligomeric α-Synuclein Species in Living Cells

2008407 citationsJournal Articlegold Open Access

Authors

Tiago F. Outeiro · Harvard University

Preeti Putcha · MaineGeneral Medical Center

Julie E. Tetzlaff · Massachusetts General Hospital

Robert Spoelgen · MaineGeneral Medical Center

Mirjam Koker · Massachusetts General Hospital

Filipe L.F. Carvalho · Harvard University

Bradley T. Hyman

Abstract

This novel application of the BiFC assay to the study of the molecular basis of neurodegenerative disorders enabled the direct visualization of alpha-synuclein oligomeric species in living cells and its modulation by Hsp70, constituting a novel important tool in the search for therapeutics for synucleinopathies.

Topics & Keywords

Parkinson's Disease Mechanisms and Treatments Genetic Neurodegenerative Diseases Alzheimer's disease research and treatments

UN Sustainable Development Goals

Life in Land

Publication Details

Published in: PLoS ONE

Volume 3, Issue 4, pp. e1867-e1867

DOI: 10.1371/journal.pone.0001867

Field-Weighted Citation Impact: 13.09