Proto-oncogenic isoform A2 of eukaryotic translation elongation factor eEF1 is a target of miR-663 and miR-744

2013103 citationsJournal Articlehybrid Open Access

Authors

A. A. Vislovukh

Gueorgui Kratassiouk · Génétique Quantitative et Évolution Le Moulon

Edoardo Porto · Centre de Génétique Moléculaire

N. L. Gralievska · Institute of Molecular Biology and Genetics

Cornelia Beldiman · Génétique Quantitative et Évolution Le Moulon

Gian Domenico Pinna · Centre National de la Recherche Scientifique

A. V. El’skaya · Institute of Molecular Biology and Genetics

Abstract

miR-663 and miR-744 mediate inhibition of the proto-oncogene eEF1A2 expression that results in retardation of the MCF7 cancer cells proliferation. Antitumour effect of resveratrol may include stimulation of the miR-663 and miR-744 expression.

Topics & Keywords

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: British Journal of Cancer

Volume 108, Issue 11, pp. 2304-2311

DOI: 10.1038/bjc.2013.243

Field-Weighted Citation Impact: 4.19