PD‐L1 (B7‐H1) expression by urothelial carcinoma of the bladder and BCG‐induced granulomata

2007438 citationsJournal Articlebronze Open Access

Authors

Brant A. Inman · Mayo Clinic

Thomas J. Sebo · Mayo Clinic

Xavier Frigola · Mayo Clinic

Haidong Dong · Mayo Clinic

Eric J. Bergstralh · Mayo Clinic

Igor Frank · Mayo Clinic

Yves Fradet · Université Laval

Abstract

Collectively, these data indicate that tumor PD-L1 may facilitate localized stage-advancement of UC and attenuate responses to BCG immunotherapy by neutralizing T cells that normally guard against cancer invasion from the epithelium into the bladder musculature.

Topics & Keywords

Bladder and Urothelial Cancer Treatments Urinary and Genital Oncology Studies Cancer Immunotherapy and Biomarkers

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Cancer

Volume 109, Issue 8, pp. 1499-1505

DOI: 10.1002/cncr.22588

Field-Weighted Citation Impact: 9.33