Interferon Regulatory Factor 6 ( <i>IRF6</i> ) Gene Variants and the Risk of Isolated Cleft Lip or Palate

2004581 citationsJournal Articlebronze Open Access

Authors

Theresa M. Zucchero · University of Iowa

Margaret E. Cooper · University of Pittsburgh

Brion S. Maher · University of Pittsburgh

Sandra Daack‐Hirsch · University of Iowa

Buena Nepomuceno

Lucilene Arilho Ribeiro · Universidade de São Paulo

Diana Caprau · University of Iowa

Abstract

DNA-sequence variants associated with IRF6 are major contributors to cleft lip, with or without cleft palate. The contribution of variants in single genes to cleft lip or palate is an important consideration in genetic counseling.

Topics & Keywords

Cleft Lip and Palate Research dental development and anomalies Craniofacial Disorders and Treatments

Publication Details

Published in: New England Journal of Medicine

Volume 351, Issue 8, pp. 769-780

DOI: 10.1056/nejmoa032909

Field-Weighted Citation Impact: 15.86

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Interferon Regulatory Factor 6 ( <i>IRF6</i> ) Gene Variants and the Risk of Isolated Cleft Lip or Palate

Authors

Abstract

Topics & Keywords

Publication Details