Prevention of Fibrosis in Experimental Colitis by Captopril: the Role of tgf-β1

200493 citationsJournal Articlebronze Open Access

Authors

Dov Wengrower

Giuliana Zannineli · University Gastroenterology

Orit Pappo · Hadassah Medical Center

Giovanni Latella · Hearing, Speech & Deaf Center

M. Sestieri · University Gastroenterology

Amancay Villanova · University Gastroenterology

Yoram Faitelson · Agricultural Research Organization

Abstract

These data demonstrate for the first time that the prophylactic administration of captopril is effective in preventing colonic fibrosis in TNBS-induced colitis. The antifibrotic action of captopril could be due to the blockade of TGFbeta-1 overexpression, and/or to a direct down-regulation of TGFbeta-1 transcript.

Topics & Keywords

Inflammatory Bowel Disease TGF-β signaling in diseases Pancreatic and Hepatic Oncology Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Inflammatory Bowel Diseases

Volume 10, Issue 5, pp. 536-545

DOI: 10.1097/00054725-200409000-00007

Field-Weighted Citation Impact: 1.94