Susceptibility to ankylosing spondylitis in twins the role of genes, HLA, and the environment

1997620 citationsJournal Article

Authors

Matthew A. Brown · Centre for Human Genetics

L G Kennedy · Royal National Hospital for Rheumatic Diseases

Alex J. MacGregor · St Thomas' Hospital

Chris Darke · Centre for Human Genetics

Emma L. Duncan · Centre for Human Genetics

Jane L. Shatford · Centre for Human Genetics

Andrew Taylor

Abstract

Susceptibility to AS is largely genetically determined, and the environmental trigger for the disease is probably ubiquitous. HLA-B27 accounts for a minority of the overall genetic susceptibility to AS.

Topics & Keywords

Spondyloarthritis Studies and Treatments Systemic Lupus Erythematosus Research Rheumatoid Arthritis Research and Therapies

UN Sustainable Development Goals

Life in Land

Publication Details

Published in: Arthritis & Rheumatism

Volume 40, Issue 10, pp. 1823-1828

DOI: 10.1002/art.1780401015

Field-Weighted Citation Impact: 11.61