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A study of the second heart sound in 112 normal adults ranging in age from 21 to 50 years is presented, along with results, in 15 patients with advanced systemic hypertension. A detailed analysis of the Q-II A and Q-II P intervals, as related to heart rate, respiration, age, and blood pressure had been performed. A linear dependence on the √RR interval was noted in both groups. With advancing age, a statistically significant decrease in the Q-II P was noted in the normal subjects. A decreased mobility of the Q-II A and Q-II P intervals with respiration was described. In hypertensive subjects, a significant prolongation of both the Q-II A and Q-II P intervals without variation in the II- A-P interval (splitting) as compared to the normal subjects was found. The effect of respiration on the splitting of the second sound was also found to be comparable to the normal for the same age group. The relationship of changes in ventricular dynamics to systemic hypertension are discussed on the basis of these findings.