Array comparative genomic hybridization and fetal congenital heart defects: a systematic review and meta‐analysis

2014131 citationsReviewbronze Open Access

Authors

F. A. R. Jansen · Leiden University Medical Center

Yair J. Blumenfeld · Stanford Medicine

Andmorgan Fisher · Elliot Hospital

J. M. Cobben · University of Amsterdam

Anthony Odibo · University of South Florida

A. Borrell · Society for Maternal-Fetal Medicine

Monique C. Haak ·

Abstract

In this review we provide an overview of published data and discuss the benefits and limitations of using aCGH. If karyotyping and 22q11 microdeletion analysis by FISH are normal, using aCGH has additional value, detecting pathogenic CNVs in 7.0% of prenatally diagnosed CHD, with a 3.4% additional yield of detecting VOUS.

Topics & Keywords

Congenital heart defects research Congenital Heart Disease Studies Prenatal Screening and Diagnostics

Publication Details

Published in: Ultrasound in Obstetrics and Gynecology

Volume 45, Issue 1, pp. 27-35

DOI: 10.1002/uog.14695

Field-Weighted Citation Impact: 4.98

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Array comparative genomic hybridization and fetal congenital heart defects: a systematic review and meta‐analysis

Authors

Abstract

Topics & Keywords

Publication Details