Ischemic Postconditioning-Mediated miRNA-21 Protects against Cardiac ischemia/reperfusion Injury via PTEN/Akt Pathway

2013125 citationsJournal Articlegold Open Access

Authors

Yingfeng Tu · Fourth Affiliated Hospital of Harbin Medical University

Lin Wan · Harbin Medical University

Yuhua Fan · Harbin Medical University

Kezheng Wang · Fourth Affiliated Hospital of Harbin Medical University

Lihong Bu · Harbin Medical University

Tao Huang · Fourth Affiliated Hospital of Harbin Medical University

Zhen Cheng

Abstract

Background: Ischemic postconditioning (IPost) protects the reperfused heart from infarction which has drawn much attention recently. However, studies to date have rarely investigated the role of microRNAs (miRNAs) in IPost. The aims of this study were to investigate whether miR-21 is involved in the protective effect of IPost against myocardial ischemia-reperfusion (I/R) injury and disclose the potential molecular mechanisms involved.

Topics & Keywords

Cardiac Ischemia and Reperfusion Fuel Cells and Related Materials Advanced Battery Technologies Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS ONE

Volume 8, Issue 10, pp. e75872-e75872

DOI: 10.1371/journal.pone.0075872

Field-Weighted Citation Impact: 9.18