Confirmation of ALDH2 as a Major Locus of Drinking Behavior and of Its Variants Regulating Multiple Metabolic Phenotypes in a Japanese Population

2011149 citationsJournal Articlebronze Open Access

Authors

Fumihiko Takeuchi · Center for Global Health

Masato Isono · National Center for Global Health and Medicine

Toru Nabika · Shimane University

Tomohiro Katsuya · Osaka University

Takao Sugiyama · Institute for Adult Diseases Asahi Life Foundation

Shuhei Yamaguchi · Shimane University

Shotai Kobayashi

Abstract

Our results confirm ALDH2 as a major locus regulating drinking behavior in the Japanese, indicating that the ALDH2 504Lys variant exerts pleiotropic effects on risk factors of cardiovascular disease among drinkers.

Topics & Keywords

Alcohol Consumption and Health Effects Diet, Metabolism, and Disease Liver Disease Diagnosis and Treatment

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation Journal

Volume 75, Issue 4, pp. 911-918

DOI: 10.1253/circj.cj-10-0774

Field-Weighted Citation Impact: 5.73