Constitutive Fragile Sites and Cancer

1984685 citationsJournal Article

Authors

Jorge J. Yunis · University of Minnesota Medical Center

A. Lee Soreng · University of Minnesota Medical Center

Abstract

Breaks were observed at 51 sites in homologous chromosomes in lymphocytes from ten humans and two great apes when cells were deprived of thymidine. The incidence of breaks was enhanced by caffeine, a substance that inhibits DNA repair in replicating cells. The locations of 20 sites were correlated with breakpoints that have been related to human malignancy.

Topics & Keywords

Genetics and Neurodevelopmental Disorders Neuroblastoma Research and Treatments Childhood Cancer Survivors' Quality of Life

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Science

Volume 226, Issue 4679, pp. 1199-1204

DOI: 10.1126/science.6239375

Field-Weighted Citation Impact: 39.35