Lactobacillus probiotic protects intestinal epithelium from radiation injury in a TLR-2/cyclo-oxygenase-2-dependent manner

2011280 citationsJournal Articlehybrid Open Access

Authors

Matthew A. Ciorba · University Gastroenterology

Terrence E. Riehl · Washington University in St. Louis

Mahil Rao · Washington University in St. Louis

Clara Moon · Washington University in St. Louis

Xueping Ee · Washington University in St. Louis

Gerardo M. Nava · Washington University in St. Louis

Monica R. Walker

Abstract

LGG or its CM reduce radiation-induced epithelial injury and improve crypt survival. A TLR-2/MyD88 signalling mechanism leading to repositioning of constitutive COX-2-expressing mesenchymal stem cells to the crypt base is invoked.

Topics & Keywords

Gastrointestinal motility and disorders Gut microbiota and health Effects of Radiation Exposure

Publication Details

Published in: Gut

Volume 61, Issue 6, pp. 829-838

DOI: 10.1136/gutjnl-2011-300367

Field-Weighted Citation Impact: 6.98

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Lactobacillus probiotic protects intestinal epithelium from radiation injury in a TLR-2/cyclo-oxygenase-2-dependent manner

Authors

Abstract

Topics & Keywords

Publication Details