Multifunctional Poly(2‐oxazoline) Nanoparticles for Biological Applications

201073 citationsJournal Article

Authors

Kristian Kempe · Friedrich Schiller University Jena

Antje Vollrath · Friedrich Schiller University Jena

Hendrik W. Schaefer · Friedrich Schiller University Jena

Tobias G. Poehlmann · Friedrich Schiller University Jena

Christoph Biskup · Jena University Hospital

Richard Hoogenboom · Eindhoven University of Technology

Stephanie Hornig

Abstract

New multifunctional copoly(2-oxazoline) nanoparticles were prepared for cell studies. The polymer contains double-bond side chains as potential reaction sites for "thio"-click reactions as well as a fluorescein label covalently bound to the polymer backbone. Using the nanoprecipitation technique, spherical nanoparticles of 200-800 nm were obtained. Confocal laser scanning microscopy measurements revealed the cellular uptake of the nanoparticles.

Topics & Keywords

Click Chemistry and Applications Advanced Polymer Synthesis and Characterization Chemical Synthesis and Analysis

UN Sustainable Development Goals

Clean water and sanitation

Publication Details

Published in: Macromolecular Rapid Communications

Volume 31, Issue 21, pp. 1869-1873

DOI: 10.1002/marc.201000283

Field-Weighted Citation Impact: 4.90